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Head of Clinical Trials
MedRhythms
My dissertation research, conducted at Dartmouth College under the guidance of Dr. Ann-Christine Duhaime, investigated the neurogenic machinery in certain areas of the brain after a brain injury. I conducted stereological analyses in the dentate gyrus of human tissue, and in the white matter of an immature piglet model of controlled cortical impact. My research, resulting in publication of 3 manuscripts, showed that injury increased the number of migrating neuroblasts in the white matter in a hemispheric-dependent manner, and that injury appeared to decrease proliferation and the generation of new neurons by 7 days after injury in the piglet.
My dissertation research spurred my interest in the field of Traumatic Brain Injury (TBI) research. For 8+ years, and through various roles with my last as the Director of Clinical Studies, I was a part of an international team of researchers called the Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) Consortium. The goals of TRACK-TBI were to describe the natural history of TBI and establish more precise methods for its diagnosis and prognosis, refine outcome assessments, and compare the effectiveness and costs of TBI care. As part of the Coordinating Center based at UCSF and led by Dr. Geoffrey Manley, the Contact PI for the consortium, I managed the expansion of the consortium in 2017 and again in 2019 to result in a total of 22 enrolling clinical sites with additional sites providing analytic support. During my tenure with TRACK-TBI, I managed multimodal observational and device trials of high complexity spanning the range of injury severity in TBI. I assisted in the development of the protocols for these studies and guided the operationalization of the protocols at the 22 TRACK-TBI study sites. I contributed to the authorship of the TRACK-TBI Outcomes Standard Operating Procedures, under the guidance of Dr. Joseph Giacino, which have become the foundation for outcome procedures for all TRACK-TBI studies. I helped train over 100+ study coordinators on the administration of these measures in a standardized format to ensure data collection integrity. In addition, I have been fortunate to contribute to a number of publications (60+) generated by this prolific team.
In 2021, I joined MedRhythms, Inc. as their Head of Clinical Trials responsible for the design, operationalization, and conduct of trials examining our robust pipeline of novel, next-generation digital therapeutics. We aim to bring these solutions to a wide range of patients suffering from neurologic impairments that can be improved through auditory-motor entrainment.