Chinese dialect other than ' Mandarin ' training for acute cerebral infarction motor aphasia promoted cortex functional connectivity

Research Objectives: Post-stroke aphasia is a cerebral vascular blockage with scanty blood supply, just as the farmland loses its nourishment yielding a barren land. The strategy is to improve soil as well as select better seed. Improving the soil is what we are all doing to improve the cerebral vascular re-canalizations; unfortunately the choice of “better seed” has not been considered. This study was to observe how the seed growth.

Design: Chinese dialect vs. ' Mandarin ' training. Chinese dialect vs healthy female volunteers. ' Mandarin ' training vs. healthy female volunteers.

Setting: University Affiliated Hospital.

Participants: 22 right-handed female patients with acute cerebral infarction motor aphasia and 20 healthy female volunteers were included.

Interventions: The phonetic semantic training was performed daily for 30 minutes for 15 consecutive days for 1 session. BOLD-fMRI scans were performed on Broca and Wernicke area. The post-processing software AFNI was used to process the images.Compared the time-signal intensity of different language training.

Main Outcome Measures: Time-signal intensity of different language training.

Results: The semantic judgment and phonetic judgment activated multiple functional brain regions distributed in the frontal, parietal, occipital, and cerebellar hemispheres on both sides. Both language tasks can effectively activate Broca area and the Wernicke area. The signal response of semantic judgment task in BA45/47 area of left inferior frontal gyrus was stronger than that of speech judgment task. In the BA44/45 area, the intensity of BLOD signal in the speech judgment task was higher than that in the semantic judgment task. In the healthy control group, there was no difference in the time signal intensity curve of the whole Broca and the Wernicke area between different language tasks (P>0.05), but the curve area of Chinese dialect group was smaller than that in the Mandarin group (P < 0.05).

Conclusions: The right cerebral hemisphere of Chinese language is involved in the processing of semantics and sound.Compared with Mandarin, Chinese dialect training for cerebral infarction motor aphasia promoted cortex functional connectivity in Broca and Wernicke areas.

Author(s) Disclosures: None.